Neural Networks for Vaccine Discovery

Time: 2023 - 2024
Location: Penn State University
Advisor: Prof. Vivek Kapur
Skills: Python, Neural Networks, Data Analysis

Focusing on reducing the wet lab costs of vaccine research, I utilized the NetMHCIIpan-4.3 Artificial Neural Network (ANN) to predict immune triggering peptides in Tuberculosis antigens, focusing on the binding pattern with MHC II. I processed large scale sequencing data and validated the model’s predictions against experimental results using R² correlation and Jaccard similarity, demonstrating the effectiveness of computational methods in identifying potential vaccine candidates.